Kunpeng Jia

MOE Laboratory of Biosystems Homeostasis & Protection and iCell Biotechnology Regenerative Biomedicine Laboratory of College of Life Sciences, Zhejiang University, Hangzhou, 310058, China

Publications

Research Article
Pan-cancer analysis of molecular characteristics and oncogenic role of PRMT5 in human cancers
Author(s): Kunpeng Jia, Lexi Huang, Yuanhao Xu and Lingjiao Xiang*

Accumulating evidence supports the involvement of PRMT5 in cancer development; however, its cross-cancer molecular features remain incompletely characterized. Here, we performed an integrated pan-cancer analysis of PRMT5 and complemented the in silico results with PRMT5 knockdown experiments in three representative cancer cell lines. PRMT5 was upregulated in most cancers and showed cancer-type-specific prognostic associations. Immune infiltration analysis revealed that PRMT5 expression was associated with an immunosuppressive microenvironment, characterized by reduced CD8+ T-cell levels in CESC and SKCM and elevated fibroblast recruitment across a broad spectrum of tumors, such as LIHC and PAAD. Enrichment analysis suggested that PRMT5-associated networks were linked to DNA/RNA metabolism and stress-response pathways. In vitro, PRMT5 silencing reduced proliferation, migration and stemnes.. Read More»
DOI: 10.5281/zenodo.20019639

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