Journal of Pharmacognosy & Natural Products

ISSN: 2472-0992

Open Access

Javier Galán

Department of Plant Biology and Ecology, University of Sevilla, Sevilla, Spain

  • Mini Review   
    Natural PPAR Agonist that Doesn't Cause Corpulence
    Author(s): Javier Galán*

    In clinical settings, PPAR (peroxisome proliferator-activated receptor gamma) agonists are utilized to combat hyperglycemia. The search for new PPAR activators, on the other hand, is fueled by the experience of undesirable side effects like weight gain. We utilized a mix of in silico, in vitro, cell-based and in vivo models to distinguish and approve regular items as promising leads for halfway original PPARγ agonists. It was predicted in silico that the natural product honokiol from the traditional Chinese medicine Magnolia bark would bind as a dimer into the PPAR ligand binding pocket. In fact, in a PPAR-mediated luciferase reporter assay, Honokiol acted as a partial agonist by binding directly to the purified LBD of PPAR. After that, the effects of Honokiol on adipogenic differentiation in 3T3-L1 pre-adipocytes and mouse embryonic fibroblasts and the stimu.. Read More»
    DOI: 10.37421/2472-0992.2022.8.196

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