Journal of Biomedical Systems & Emerging Technologies

Organization for Innovation and Social Collaboration, Shizuoka University, Johoku, Hamamatsu, 432-8561, Japan

Publications

• Research Article   
  Transdermal Drug Delivery of Adenosine by Microplasma with Iontophoresis and DMSO
  Author(s): Jaroslav Kristof*, Marius Blajan, Ryo Yokoyama, Fariha Mustafa, Ahmad Guji Yahaya and Kazuo Shimizu
  
  Medication brings negative effects regarding the method of the drug administration, such as risk of infections and metabolism of drugs. Transdermal drug delivery can avoid these problems. Microplasma discharge treatment was used to overcome the skin barrier. TEM observation of the untreated and microplasma treated skin confirmed the effect of microplasma on lipid lamellae. Franz diffusion cell was used to investigate permeation of Adenosine through Yucatan micropig skin. The amount of the penetrated drug and the drug retained inside the skin was measured by HPLC. We compared Adenosine permeation through the untreated skin, iontophoreticaly pre-treated skin with FeSO4â??7H2O, iontophoreticaly pre-treated skin with FeSO4â??7H2O followed by microplasma treatment, and DMSO treated skin. Iontophoretic pre-treatment with FeSO4â??7H.. Read More»
  DOI: 10.37421/bset.2021.S1.006

  Abstract HTML PDF