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Medicinal Chemistry

ISSN: 2161-0444

Open Access

Ilango K

Interdisciplinary Institute of Indian System of Medicine (IIISM), Department of Pharmaceutical Chemistry, SRM Institute Science and Technology, Kattankulathur, Tamil Nadu, India

Publications
  • Review   
    The Journey of Thiazolidinediones as Modulators of PPARs for the Management of Diabetes: A Critical Review
    Author(s): Munwar S* and Ilango K

    Thiazolidinediones are a class of well-established antidiabetic drugs, also named as glitazones. Thiazolidinedione structure has been an important structural domain of research, involving design and development of new drugs for the treatment of type 2 diabetes. Extensive research on the mechanism of action and the structural requirements has revealed that the intended antidiabetic activity in type 2 diabetes is due to their agonistic effect on peroxisome proliferator-activated receptor (PPAR) belonging to the nuclear receptor super family. Glitazones have specific affinity to PPARγ, one of the subtypes of PPARs. Certain compounds under development have dual PPARα/γ agonistic activity which might be beneficial in obesity and diabetic cardiomyopathy. Interesting array of hybrid compounds of thiazolidinedione PPARγ agonists exhibited therapeutic po.. Read More»
    DOI: 10.37421/2161-0444.2020.10.547

    Abstract HTML PDF

Google Scholar citation report
Citations: 6627

Medicinal Chemistry received 6627 citations as per Google Scholar report

Medicinal Chemistry peer review process verified at publons

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