Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

Gamal Shams

Department of Pharmacology, Faculty of Veterinary Medicine, Zaazig Univeristy, Egypt

  • Research   
    Short and Long Term Administration of Gold Nanorods Induces Hepatic and Renal Toxicities in Male Albino Rats
    Author(s): Mahmoud A A Said*, Ahmed S Abdoon, Sayed A Aziz, Gamal Shams, Al-Sayed R Al-attar, M Ihab Fetouh and Sameh M El Nabtity

    Gold nanoparticles are known by its good penetrating ability and translocation into cells. Despite their convenience, they can induce biochemical abnormalities and tissue toxicity. This study aimed to investigate the possibility of hepato-renal toxicities induced by gold nanorods (AuNRs) on liver and kidney tissues at short and long term basis. The experimental design was subdivided into short term study (AuNRs 300 μg/kg body weight i.p) and long term study (AuNRs 30 μg/kg body weight i.p), where adult male albino rats were used and allocated into two equal groups. The first group received IP injection of normal saline 0.9% and the second group received AuNRs. At the end of the experiment, five animals from each group were sacrificed and blood was collected on plain test tubes for biochemical study. Liver and kidney tissues were collected from both groups, and preserved a buffer.. Read More»
    DOI: 10.37421/2157-7099.21.12.610

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