Journal of AIDS & Clinical Research

ISSN: 2155-6113

Open Access

Christos Petropoulos

Monogram Biosciences, South San Francisco, CA, Laboratory Corporation of America ® Holdings, USA

  • Research Article   
    HIV-1 DNA Resistance Testing Informs the Successful Switch to a Single Tablet Regimen
    Author(s): Milka A. Rodriguez*, Anthony Mills, Adam Stoker, Suqin Cai, Dusica Curanovic, Christos Petropoulos and Charles Walworth

    Background: HIV-1 DNA drug resistance testing is increasingly used to guide antiretroviral (ARV) regimen switches in the setting of viral suppression. In this single-arm study, HIV-1 DNA resistance testing was used to assess eligibility for the fixed-dose combination of abacavir/ dolutegravir/lamivudine in the context of a switch study evaluating changes in bone mineral density in HIV-1 positive adults ages 50 years and older. Methods: Study subjects had viral loads which were <50 copies/mL at study screening. Susceptibility to each component of the switch regimen was assessed using an HIV-1 DNA genotypic resistance assay. A regimen switch was made only when the subject’s virus was sensitive to each component of the switch regimen. Viral load measurements were obtained per study protocol through weeks 24 and 48. Results: At week 24, the HIV-1 RNA viral load was <50 copies/.. Read More»

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