Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States
Research Article
Safety and Efficacy of Novel Epidural Clonidine Micropellets for Lumbosacral Radiculopathy
Author(s): Nagy A Mekhail*, Ali R Rezai, Pragya B Gupta, W Porter McRoberts, Gregory J Fiore, Bryan A Jones, Lou-Anne G Acevedo-Moreno, Chris J Gilligan and Ramsin M Benyamin
Background: Chronic back and leg pain is a leading cause of disability and results in a significant health care expenditure. Options such as physical therapy, corticosteroids Epidural Injections (ESI) or spine surgery have limited long term benefit and may cause significant morbidity. Clonidine has anti-neuropathic pain and anti-inflammatory properties. A novel, slow-release biodegradable polymer (Poly (D, L-lactide) clonidine micropellets deliver sustained, high clonidine levels and may provide prolonged pain relief with minimal systemic side effects. Methods: A pilot multicenter investigation of the safety, pharmacokinetics (PK) and effectiveness of clonidine micropellets in patients with chronic lumbosacral radiculopathy. Three sequential cohorts of 18 subjects each received a single epidural injection of clonidine 0.325 mg, 0.975 mg or 1.95 mg (1, 3 or 6 micropellets, respectively.. Read More»
DOI:
10.37421/jcnn.2020.3.109
Journal of Clinical Neurology and Neurosurgery received 2 citations as per Google Scholar report
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