Journal of Molecular Histology & Medical Physiology

ISSN: 2684-494X

Open Access

Cavin Sharkey

Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada

  • Mini Review   
    The Role of Intestinal Distension in Shaping Neuronal Activity in the Enteric Nervous System of Adult Mice
    Author(s): Cavin Sharkey*

    The Enteric Nervous System (ENS) plays a pivotal role in governing the motor, secretory, and defensive functions of the gastrointestinal tract. These enteric neurons intricately process both mechanical and chemical cues from the gut lumen, translating them into intricate motor responses. However, the precise manner in which intact enteric neural networks react to shifts within the gut environment remains a puzzle. To unravel this enigma, we conducted live-cell confocal recordings, capturing intracellular calcium activity in neurons extracted from intact portions of mouse intestine. Our aim was to investigate how neurons respond to various luminal mechanical and chemical stimuli. Utilizing specialized Wnt1, ChAT, and Calb1-GCaMP6 mice, we focused on neurons residing in the jejunum and colon. Our experimental design encompassed an examination of neuronal calcium .. Read More»
    DOI: 10.37421/2684-494X.2023.8.66

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