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Journal of Computer Science & Systems Biology

ISSN: 0974-7230

Open Access

Boris Pirkic

Clinic for Surgery, Orthopedics and Ophthalmology, Veterinary Faculty, University of Zagreb, Heinzelova ul. 55, 10000 Zagreb, Croatia

Publications
  • Research Article   
    Evaluation of the Efficacy of Cancer Drugs by Using the Second Largest Eigenvalue of Metabolic Cancer Pathways
    Author(s): Drasko Tomic*, Karolj Skala, Lado Kranjcevic, Boris Pirkic, Sanja Stifter and Iva Smit

    Cancer is a system with thousands of genes and proteins with the complex interactions between them. By examining the cancer drug activity on only part of this system, we do not know in which direction the whole system will evolve, and whether therapy will be useful or not. This is one of the main reasons why cancer therapies still do not meet our expectations. In order to find more effective anticancer therapies, it is important to consider the impact of drugs on the entire cancer system. The second largest eigenvalue plays a key role in complex systems optimization. The algorithms minimizing the second largest eigenvalue of graphs have been already used to speed up processes in computer networks and differential cryptanalysis. Based on the aforementioned, it could be assumed that maximizing the second highest eigenvalue could slow down the processe.. Read More»

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Google Scholar citation report
Citations: 2279

Journal of Computer Science & Systems Biology received 2279 citations as per Google Scholar report

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