Department of Obstetrics and Gynecology, University of Calgary, Alberta, Canada
Perspective
Altitude-Induced Differential Effects on Potassium Channel-Mediated Vasodilation in Pregnant Human Myometrial Arteries
Author(s): Anna Lorca*
Residing at high altitudes (>2500 m or 8200 ft) leads to a decline in blood flow through the uterine artery during pregnancy, contributing to a higher
occurrence of preeclampsia and intrauterine growth restriction. Nevertheless, not all pregnancies experience the effects of prolonged hypoxia associated
with high-altitude living. Potassium (K+) channels play a pivotal role in the uterine blood vessel adjustments during pregnancy, promoting
the relaxation of muscle tone and an augmentation in blood circulation. We postulated that in pregnancies with normal fetal growth at high altitudes,
there is an augmented K+ channel-mediated vasodilation in myometrial arteries compared to those in healthy pregnant women residing at lower
altitudes (approximately 1700 m). Through the manipulation of two K+ channels the ATP-sensitive (KATP) and l.. Read More»
DOI:
10.37421/2684-494X.2023.8.72
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