Journal of Microbial Pathogenesis

ISSN: 2684-4931

Open Access

Angélica Schulz

Department Pathological Anatomy, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, Chile

  • Opinion   
    Neutrophil Extracellular Traps and High Presence of NETotic Cells in Vaginal Discharges of Women with Vaginitis: An Exploratory Study
    Author(s): Angélica Schulz*

    Infectious vaginitis is a microbiological syndrome of great importance in public health that affects millions of women worldwide. However, no studies have explored the phenomenon of the production of the neutrophil extracellular traps (NETs) that are released into the female reproductive tract in these pathologies. This study aimed to determine the presence of NETosis in vaginal discharges of women with bacterial vaginosis, candidiasis, and trichomoniasis by characterizing NETs. Extracellular DNA with neutrophil elastase and citrullinated histones was identified to confirm the NET components (n = 10). The concentration, phenotypes of NETs, and number of NETotic cells were determined. The results showed an increase in NETotic cells in women with Candida albicans (CA) and Trichomonas vaginalis (TV) and an increase in NETs in TV-induced vaginitis. Samples of Women.. Read More»
    DOI: 10.37421/2684-4931.2022.6.128

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