Department of Experimental Treatment, Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq
Research Article
The investigation of lysosomal membrane-associated glycoprotein 3 (LAMP3) on stromal cells in Iraqi stomach cancer patients
Author(s): Raghad Khalid Mwafaq*, Alsafa Nassr Khalaf Harbi, Shaimaa Khalid Moufak, Abeer Sajid Abd Ali, Alyaa Kareem Abood and Eman Ghazi Metaab
Background: Lysosomal Membrane-Associated Glycoprotein 3 (LAMP3) also known as cluster of differentiation CD63 is a member of tetraspanin, and a kind of membrane protein (III) is modified by N-glycosylation. It is found in lysosomes and is preferred in different types of cancer. Tumor stromal cells in the primary stage can induce tumorigenesis in numerous types of cancers. Also, stimulates metastatic growth by supplying the pre-metastatic niche. However, it can stimulate invasion and metastasis of tumor cells to other organs while maintaining survival and proliferation, therefore being effective in colonizing in metastatic sites. Objective of this study is to appreciate the expression of – LAMP3 in stromal cancer cells in patients with stomach cancer and detect the linkage between the expression of this protein and clinicopathological parameters, it is the first.. Read More»
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