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Chemical Sciences Journal

ISSN: 2150-3494

Open Access

Ali M Hassan

Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt

Publications
  • Research Article   
    Cloud Point Pre-concentration with Spectrophotometric Detection for Determination of Oxymetazoline in Pharmaceutical Formulations
    Author(s): Khalid Wahdan*, Zaid Alnedawi, Ali M Hassan, Hind Hadi and Ahmed Shabana

    Simple and sensitive method was proposed for enrichment and determination of Oxymetazoline (OMZ) in its pharmaceutical matrix through Cloud Point Extraction (CPE) technique, the method depends on forming misciles by using non-ionic surfactant triton-x114 to enrichment colored azo dye product that results from diazotization-coupling reaction of the OMZ drug with diazotized metoclopramide (also drug) in alkaline medium and subsequently detected spectrophotometrically at 510 nm. The optimal reaction and pre-concentration (such as PH, surfactant concentration, temperature and centrifugations time) conditions optimized, under the optimized conditions, the analytical characteristics were obtained, linearity was obeyed in the range of 0.05-17.0 μg.ml-1 the limit of detection and the limit of quantification calculated to be 0.047 and 0.15 μg.ml-1, respecti.. Read More»

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