Journal of Clinical & Medical Genomics

ISSN: 2472-128X

Open Access

Zhao Shi

IR Iran

  • Review Article
    The Crosstalk between Micro RNA and Iron Homeostasis
    Author(s): Zihui Xu, Zhao Shi and Yujing LiZihui Xu, Zhao Shi and Yujing Li

    Iron is a micronutrient essential for fundamental cellular processes. Iron deficiency has been proven to be the leading course of some blood diseases. Though essential, iron overload may contribute to the generation of free radicals capable for cell damaging. As such, the maintenance and control of iron homeostasis is critical to prevent either iron deficiency or iron overload toxicity. Iron homeostasis is largely coordinated by a family of Iron Regulatory Proteins (IRP) that functions to control iron uptake, storage, transport, and utilization. More recently, iron metabolism has also been implicated in the modulation of microRNA (miRNA), a class of small non-coding RNA recognized as the major regulation mechanism for gene expression at post-transcriptional level. Vice versa, miRNAs have been demonstrated to regulate the expression of genes associated with iron acquisition (transferri.. Read More»
    DOI: 10.4172/2332-0672.1000112

    Abstract PDF

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