Medicinal Chemistry

Yannicca WYChang

Publications

• Review Article
  Roles of Serine Protease Inhibitor Kazal type 1 (SPINK1) in Prostate Cancer
  Author(s): Chengwu Shen, Jing Zhang, Mei Qi, Yannicca WYChang and Bo HanChengwu Shen, Jing Zhang, Mei Qi, Yannicca WYChang and Bo Han
  
  Altered genes that play a driving role in cancer development can often serve as specific diagnostic markers, criteria of molecular classification and therefore potential therapeutic targets. Serine protease inhibitor Kazal type 1 (SPINK1), also known as pancreatic secretory trypsin inhibitor or tumor-associated trypsin inhibitor, encodes a 56 amino acid secreted peptide, and its normal function is thought to be the inhibition of serine proteases such as trypsin. Recent studies have indicated marked overexpression of SPINK1 defines an aggressive molecular subtype of ETS (erythroblastosis virus E26 transformation-specific) fusion-negative prostate cancer ((PCa) patients. SPINK1 may act as an autocrine growth factor and promotes PCa growth and invasion. Most recently, we suggested that SPINK1 induces epithelial-mesenchymal transition (EMT) through EGFR s.. Read More»
  DOI: 10.4172/2161-0444.1000220

  Abstract PDF