Neurological Disorders

Tinglei Li

Publications

• Research Article
  Investigation of an Optimized Protocol for Brucine-Induced Seizure Model
  Author(s): Xinxin Fan, Tinglei Li, Jinmei Li, Yingying Li and Dan ChenXinxin Fan, Tinglei Li, Jinmei Li, Yingying Li and Dan Chen
  
  Object: Strychnine has been reported to develop seizure models. As its analogue, brucine may also have such property. The aim of the study was to create a chemoconvulsant model of seizures by fractionated administration of brucine. Methods: Healthy male Sprague-Dawley rats (n=140) were allocated randomly into three groups: experimental group， normal saline control group and alcohol control group. Rats in experimental group were then randomly divided into six groups during the kindling process: three of the six subgroups were single-dose subgroups, while another three were fractionated-dose subgroups. Rats from three single-dose subgroups (n=20 for each subgroup) received single injection of brucine at three various dose levels (91 mg/kg, 100 mg/kg and 110 mg/kg, respectively); rats from the other three fracti.. Read More»
  DOI: 10.4172/2329-6895.1000156

  Abstract PDF