Journal of Nephrology & Therapeutics

ISSN: 2161-0959

Open Access

Takao Saruta


  • Research Article
    Canine Model of Cardiorenal Failure
    Author(s): Hiromichi Suzuki, Akira Matsumoto, Marohito Murakami, Mareo Naitoh and Takao SarutaHiromichi Suzuki, Akira Matsumoto, Marohito Murakami, Mareo Naitoh and Takao Saruta

    The heart and the kidneys act in tandem to regulate blood pressure, vascular tone, diueresis and to maintain intravascular volume homeostasis. Besides, the kidneys have a neuroendocrine function with interdependent physiological actions regulated by the renin-angiotensin-aldosterone system, sympathetic nervous system, and vasopressin and aterial natriuretic peptide. To investigate these complex pathophysiological mechanisms, a canine model for Congestive Heart Failure (CHF) compromised with Renal Dysfunction (RF) was used, to characterize the hemodynamic and neurohumoral aspects of renal function in 21 dogs. Five dogs were used as controls. Bipolar epicardial pacemaker leads were implanted at the apex of the right ventricle in 8 dogs and the dogs were subjected to ventricular pacing at 250-270 beats/min with an external pacemaker (Nihon Kohden) for a period .. Read More»
    DOI: 10.4172/2161-0959.1000127

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