Low-Dose Ritonavir-Boosted Atazanavir (200/100 mg) Maintained a High Virological Efficacy Up To 4 Years in Treatment-Experienced HIV-1 Infected Adults: A Prospective Cohort Study from Asia
Author(s): Anchalee Avihingsanon, Tanakorn Apornpong, Stephen J Kerr, Wirach Make-a-nantawat, Narukjaporn Thammajaruk, Supalak Phonphithak, Reshmie A Ramautarsing, Amanda Clarke, Praphan Phanuphak, David M Burger, Kiat Ruxrungtham and HIV-NAT 006 Study TeamAnchalee Avihingsanon, Tanakorn Apornpong, Stephen J Kerr, Wirach Make-a-nantawat, Narukjaporn Thammajaruk, Supalak Phonphithak, Reshmie A Ramautarsing, Amanda Clarke, Praphan Phanuphak, David M Burger, Kiat Ruxrungtham and HIV-NAT 006 Study Team
Background: HIV requires lifelong treatment so ARV dose optimization is important for long-term efficacy and safety. Previously, low-dose atazanavir (ATV)/ritonavir(r) plus 2 NRTIs in HIV-infected Thai patients provided adequate plasma ATV concentrations and reduced risk of hyperbilirubinemia. However, long-term efficacy and safety data is limited. Methods: 127 HIV-infected adults on ATV/r200/100mg plus 2 NRTIs were prospectively followed in Thailand. CD4 cell counts, HIV-RNA, and safety parameters were performed every 6 months. Estimated glomerular filtration rate (eGFR) was calculated by chronic kidney disease epidemiology (CKD-EPI). ATV plasma concentrations (ATV Ctrough) were assessed. Results: Median body weight was 60 kg and 50% were females. Previous regimens were mainly standard dose ATV/r (54%) and lopinavir/r (29%). 93% of them were on te.. Read More»
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Jan 01, 1970
Accepted Date: Jan 01, 1970
Published Date: Jan 01, 1970