Neurological Disorders

ISSN: 2329-6895

Open Access

Sawarkar Vaibhav


  • Review Article
    Conotoxins: Possible Therapeutic Measure for Huntingtons Disease
    Author(s): Pallavi Bhosle and Sawarkar VaibhavPallavi Bhosle and Sawarkar Vaibhav

    Huntington’s disease (HD) is a genetic disorder with autosomal dominant inheritance with progressive degeneration of neurons. It is characterized by affective, cognitive, behavioral, and motor dysfunctions. 3 nitropropionic acid is well established animal model which initiates a complex series of neurochemical and signaling changes that lead to pathological events including neuronal excitotoxicity by excessive glutamate release, neuroinflammation and energy impairment. Excitotoxins like NMDA and kainic acid which binds to these receptors to release high levels of glutamate that can cause excitotoxicity by allowing high levels of calcium ions (Ca2+) to enter the cell. Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes increase apoptosis, oxidative stress and energy impairment thereby causing .. Read More»
    DOI: 10.4172/2329-6895.1000129

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