Journal of Computer Science & Systems Biology

Rishu Vallabhu

Publications

• Research Article
  A Systems Biology View of the Spliceosome Component Phf5a in Relation to Estrogen and Cancer
  Author(s): Rishu Vallabhu, Eva Falck and Angelica LindlöfRishu Vallabhu, Eva Falck and Angelica Lindlöf
  
  Cancer is a broad term for a wide spectrum of diseases and which involves the alteration in expression levels of several hundreds of genes. As such, the study of the disease from a systems biology point of view becomes rational, as the properties of a system as a whole may be very different from the properties of its individual components. However, understanding a network at the systems level not only requires knowledge about the components of the network, but also the interactions between them. Here, a systems biology view of the rat PHD finger protein 5A (Phf5a) gene was attempted; a gene previously identified as aberrantly expressed in estrogen dependent endometrial adenocarcinoma tumors from both rat and human. Phf5ais a highly conserved cysteine rich (C4HC3) zinc finger and such proteins predominantly have a role in chromatin mediated transcripti.. Read More»
  DOI: 10.4172/jcsb.1000156

  Abstract PDF