Journal of Molecular Biomarkers & Diagnosis

Rania Hassan Khalifa

Publications

• Case Report
  Estrogen Receptor Genes Polymorphisms and Susceptibility to Juvenile and Adult Onset Systemic Lupus Erythematous in Egyptian Patients
  Author(s): Rania Hassan Khalifa, Abeer Nabil Mokbel, Mohamed Abdallah Kamel, Engy Mohammed and Hend Hamed TamimRania Hassan Khalifa, Abeer Nabil Mokbel, Mohamed Abdallah Kamel, Engy Mohammed and Hend Hamed Tamim
  
  Abstract Background:Estrogens, acting through their cellular receptors namely alpha and beta, have a role in the development of systemic lupus erythematosus (SLE). Objectives: To investigate whether polymorphisms of ESR1 and ESR2 genes is related to the susceptibility of juvenile (jSLE) and adult Systemic lupus erythematosus (aSLE) and to detect their association with clinical and laboratory characteristics of the disease. Methods: Genomic DNA was extracted from 32 adult onset SLE (aSLE), 33 juvenile onset SLE (jSLE) and 60 age and gender matched controls. Genotyping of ESR1 and ESR2 was done using the restriction fragment length polymorphism (RFLP) and tetra primer ARM-PCR methods respectively. Results: There was a statistically significant difference in the ge.. Read More»
  DOI: 10.4172/2155-9929.1000245

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