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Journal of Nephrology & Therapeutics

ISSN: 2161-0959

Open Access

Oliveira JC


Portugal

Publications
  • Research Article
    Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis
    Author(s): Ana Rocha, Bravo F, Beiro I, Vizcano J, Oliveira JC and Lobato LAna Rocha, Bravo F, Beiro I, Vizcano J, Oliveira JC and Lobato L

    Aim: The detection and prognosis of nephropathy in transthyretin amyloidosis depends on albuminuria and renal function. Knowing that urinary levels of alpha-1 microglobulin and beta-2 microglobulin reflect tubular dysfunction while urinary alpha-2 macroglobulin implies glomerular damage, we decide investigate the diagnostic value of these markers in the patients with transthyretin amyloidosis. Methods: Serum and urinary samples collected from 30 patients and 11 asymptomatic carriers were tested for alpha-1 microglobulin, beta-2 microglobulin, alpha-2 macroglobulin, albumin, creatinine and cystatin C. Results: Pathological urinary alpha-1 microglobulin was detected in 17 patients, beta-2 microglobulin in 6 and alpha-2 macroglobulin in 5; 5 patients had albuminuria (mg/g creatinine) 30-300 and in 20 patients values >300 were present. Asymptomatic carriers.. Read More»
    DOI: 10.4172/2161-0959.1000181

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