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Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Nasir M. Idkaidek

College of Pharmacy, Petra University,
Amman
Jordan

Publications
  • Research Article
    Effect of Replicate Design on Drug Variability and Bioequivalence in Humans
    Author(s): Naji M. Najib, Isam Salem and Nasir M. IdkaidekNaji M. Najib, Isam Salem and Nasir M. Idkaidek

    The purpose of this study is to investigate the effect of using replicate design on the intra/inter subject variability and bioequivalence of drugs in healthy volunteers. Model drugs used for analysis were amoxicillin/clavulanic acid combination. 24 healthy subjects participated in this study using 4-phase replicate cross over design. Individual disposition kinetic parameters of areas under plasma concentrations (AUC0-t) and maximum concentration (Cmax) were calculated by non-compartmental analysis using Kinetic program V 4.2 using all phases. The 90 % confidence intervals for log-transformed AUC0-t and Cmax were calculated for phases I & II; then for phases I, II and III; and for phases I, II, III and IV respectively. The intra and inter-subject variability values did not show a trend to decrease by the increase in phases included in analysis in both drugs and for both parameters.. Read More»
    DOI: 10.4172/1948-593X.1000003

    Abstract PDF

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Citations: 3099

Journal of Bioanalysis & Biomedicine received 3099 citations as per Google Scholar report

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