Journal of Tissue Science and Engineering

Matthew Szarko

Publications

• Research Article
  Decellularization of Human Lip
  Author(s): Hiba Khan, Matthew Szarko and Peter ButlerHiba Khan, Matthew Szarko and Peter Butler
  
  Introduction: Perioral tissue loss commonly requires surgical reconstruction. Autologous tissue transfer result in poor functional and aesthetic outcomes and allogenous transplantation of tissue requires lifelong immunosuppression. There is a clinical need for a cell scaffold, which could be seeded with the patients own cells to create an immunogenically inert perioral tissue replacement. Decellularized human lip may provide the answer. Methodology: To the authors knowledge this was the first time human lip has been decellularized. Four existing protocols shown to be successful at removing cells from either muscle or dermis were used to decellularize human lip in an attempt to identify an optimal protocol. Results: Three of the four protocols proved to be successful at achieving decellularization of the .. Read More»
  DOI: 10.4172/2157-7552.1000149

  Abstract PDF