Journal of AIDS & Clinical Research

Maria Vittoria Cossu

Publications

• Research Article
  The Role of Therapeutic Drug Monitoring and Pharmacogenetic Testing in the Management of HIV Infection: A Review
  Author(s): Amedeo Capetti, Noemi Astuti, Maria Vittoria Cossu, Giuliano Rizzardini and Laura CarenziAmedeo Capetti, Noemi Astuti, Maria Vittoria Cossu, Giuliano Rizzardini and Laura Carenzi
  
  One of the less acknowledged tools in the international guidelines of combination antiretroviral therapy (cART) for HIV-1 infection is therapeutic drug monitoring (TDM). Yet anywhere there is a Clinical Pharmacology Unit or other facility for measuring plasma drug concentrations, physicians often measure the plasma levels of antiretrovirals as well as of comedications and find it useful. The aim of this article is to provide an overview of how relevant it is for a clinician to assess individual drug levels. Moreover we wanted to investigate to what extent the field is already assisted by web-based tools (i.e.: drug interaction charts). Finally we tried to look how pharmacogenetics may reduce the need for TDM, and whether this diagnostics is cost-effective. We searched PubMed by “drug interactions and HIV”, “drug level and HIV”, &ldquo.. Read More»
  DOI: 10.4172/2155-6113.1000458

  Abstract PDF