Medicinal Chemistry

Li Chen

Publications

• Research Article
  Pharmacological Activities and Progress in Structure Modification of Salidroside
  Author(s): Xuewei Luo, Na Bao, Li Chen and Jianbo SunXuewei Luo, Na Bao, Li Chen and Jianbo Sun
  
  Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal (TCM) plant, and has displayed a broad spectrum of pharmacological properties, such as resisting anoxia, antiradiation and antifatigue. In addition, it has low toxicity as traditional Chinese medicinal plant. However, the bioavailability of salidroside is low because of its instability for hydrolase. Lots of researchers modified the structure of salidroside to enhance its bioactivity. This paper summarizes the structure modification and activities study of salidroside in recent ten years, and preliminary discuss the structure-activity relationship of salidroside analogues, which hope to provide new ideas of modification in future. .. Read More»
  DOI: 10.4172/2161-0444.1000434

  Abstract PDF