West Virginia University Medical School, USA
Currently we study inflammation by measuring oxidative processes and genetic activation of inflamed tissues and cells. We have examined a variety of air-borne particles which can cause inflammation and eventually fibrosis. We believe the development of fibrosis (scarring) is due to inflammation which occurs chronically. Therefore, by making the particles less toxic (by coating), or by removing particles, the toxic load could be lightened. If that is not the case, then management of the system of chronic inflammation is necessary. We have been successful in regulating the inflammation ,from silica, asbestos and coal in the lung. We are developing new methods (including genetic probes) to control diseases such as black lung, silicosis, fibrosis and emphysema.
Research is centered in two main areas: chemotherapy and inflammation. These studies include an examination of antimicrobial, antiviral, antimal, and anticancer drugs. Other research is involved with host defense systems and the drugs that affect them.
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