Medicinal Chemistry

Hong-Ji Li

Publications

• Review Article
  Improved Gastrodin Production of Biotransformation Conditions by Cultured Cells Armillaria luteo-virens Sacc and the Anti-inflammatory Activity In Vivo
  Author(s): Yong-Wu Niu, Hong-Ji Li, Ya-Chen Dong, De-Qin Xu and Qi-He ChenYong-Wu Niu, Hong-Ji Li, Ya-Chen Dong, De-Qin Xu and Qi-He Chen
  
  Gastrodin (GAS), the main bioactive component of G. elata Blume, has important pharmaceutical and functional activities. The aim of this study is to produce GAS from p-2-hydroxybenzyl alcohol (HBA) through biotransformation. The conversion of exogenous HBA into GAS compound was conducted using cell suspension cultures of Armillaria luteo-virens Sacc. The bioconversion conditions were fully optimized with response surface methodology (RSM), turning out that the optimal transformation conditions composed of 3 mg/mL HBA, 6.5 g/30 mL inoculums level, 1.5% Tween 80, pH 4.5, and transformation temperature at 23°C. Under the optimized conditions, the conversion productivity of GAS reached the highest value (5.65 ± 0.45 mg/L). Verified experiments further validated that the optimized conditions were suitable for predicting the actual process of HBA transformation i.. Read More»
  DOI: 10.4172/2161-0444.1000348

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