Journal of AIDS & Clinical Research

Hong Shang

Publications

• Research Article
  Decreased IRF7 Expression Contributes to Deficient IFN-�Ž�± Production of Plasmacytoid Dendritic Cells in Chronic HIV-1 Infected Men who have Sex with Men
  Author(s): Wenqing Geng, Sha Li, Xuejie Fan, Fang Gao, Hualu Cui, Hong Sun, Zining Zhang, Yongjun Jiang and Hong ShangWenqing Geng, Sha Li, Xuejie Fan, Fang Gao, Hualu Cui, Hong Sun, Zining Zhang, Yongjun Jiang and Hong Shang
  
  Background: Deficient interferon (IFN)-α production of plasmacytoid DCs (pDCs) from HIV-1-infected individuals in response to virus or toll-like receptor (TLR) stimulation has been reported. pDCs express TLR7 and TLR9, but whether and how the TLR pathway contributes to the deficiency has not been well addressed. Methods: Twenty-six subjects with HIV-1 infection were recruited from a chronic HIV-1 infection (CHI) cohort of men who have sex with men (MSM) and 15 HIV-1 negative healthy MSM were used as normal controls (NCs). Maturation markers (CD80, CD86, CD83, CD40, CCR7), TLR7 and TLR9, nuclear factor κB (NF-κB) and interferon regulatory factor 7 (IRF7) expression were detected using surface and intracellular multicolor flow cytometry. Intracellular IFN-α production of pDCs was measured in response to R848 (TLR7 agonist) and ODN2216 (.. Read More»
  DOI: 10.4172/2155-6113.1000548

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