Medicinal Chemistry

Hao Zhang

Publications

• Research Article
  Synthesis, DNA-binding Properties and Quantitative Structure-Activity Relationships on Ruthenium(II) Complexes with Calf-Thymus DNA
  Author(s): Hao Zhang, Fan Yang, Qiong Wu, Si-Yan Liao, Ping Liu, Xi-Cheng Wang, Li Li, Shuang-Yan Zhang and Wen-Jie MeiHao Zhang, Fan Yang, Qiong Wu, Si-Yan Liao, Ping Liu, Xi-Cheng Wang, Li Li, Shuang-Yan Zhang and Wen-Jie Mei
  
  A series of novel ruthenium(II) complexes with electron-donor or electron-acceptor groups in intercalative ligands, [Ru(phen)2(o-MOPIP)]2+(1), [Ru(phen)2(o-MPIP)]2+(2), [Ru(phen)2(o-CPIP)]2+(3) and [Ru(phen)2(o-NPIP)]2+(4) have been synthesized and characterized with elementary, ES-MS, 1H NMR, electronic absorption and emission spectra. The binding properties of these complexes to CT-DNA have been investigated by spectroscopy and viscosity experiments. It’s illustrated that these complexes bind to DNA in a non-classical intercalation mode and their intrinsic binding constants (Kb) for 1, 2, 3 and 4 are calculated as 1.1, 0.35, 0.53 and 1.7 × 105 M-1, respectively. The Quantitative Structure-Activity Relationships (QSAR) of these ruthenium complexes, as well as some other ruthenium complexes congers has been investigated, and a linearity equation have been .. Read More»
  DOI: 10.4172/2161-0444.1000338

  Abstract PDF