Alternative & Integrative Medicine

Guanan Wang

Publications

• Research Article
  Acupuncture Regulates the Notch Signaling Pathway in Bone Marrow Cells to Alleviate Cyclophosphamide-Induced Myelosuppression in S180 Tumor Bearing Mice
  Author(s): Mei Lu, Dongdong Yu, Daming Cao, Yingchun Teng, Jianwei Li, Guanan Wang, Yanchao Wang and Li ZhangMei Lu, Dongdong Yu, Daming Cao, Yingchun Teng, Jianwei Li, Guanan Wang, Yanchao Wang and Li Zhang
  
  Objective: To evaluate the protein expression and distribution of Notch signaling-related, differentially expressed genes (DEGs) in the bone marrow cells of S180 tumor bearing mice. Additionally, verification of acupuncture regulated protein expression of these DEGs to protect bone marrow stem cells and alleviate cyclophosphamide (CTX) chemotherapy-induced myelosuppression was examined as well. Methods: Healthy male Kunming mice were inoculated with S180 sarcomas and further divided into blank control (group A), CTX group (group B), acupuncture (group C), and moxibustion (group D) groups. Animals in groups B, C, and D were intraperitoneally injected with single dose of 150 mg/kg CTX to generate the myelosuppressive model; while animals in group A were injected with an equivalent volume of sterile saline. After immobilizing the animals, mice .. Read More»
  DOI: 10.4172/2327-5162.1000229

  Abstract PDF