Journal of Nephrology & Therapeutics

Giorgio Graziani

Publications

• Review Article
  Anti-Phospholipase A2 Receptor Antibodies in Membranous Nephropathy:from Bench to the Patient
  Author(s): Roberto Assandri, Alessandro Montanelli, Marta Monari, Manuel A Podestà and Giorgio GrazianiRoberto Assandri, Alessandro Montanelli, Marta Monari, Manuel A Podestà and Giorgio Graziani
  
  Membranous Nephropathy (MN) is the leading cause of nephrotic syndrome in adults. Primary or idiopathic Membranous Nephropathy (iMN) has been considered as an organ-specific autoimmune disease with an unknown aetiology. By contrast, secondary membranous nephropathy has been described as the expression of a systemic autoimmune response to malignancy or bacterial/viral infections. In the majority of iMN cases, glomerular lesions are determined by autoantibodies against a podocyte membrane protein, the M-type of phospholipase A2 receptor 1 (PLA2R1). Several studies have suggested that the detection of anti-PLA2R1 in patients sera with nephrotic syndrome may be pathognomonic of iMN, thus obviating the need for a diagnostic renal biopsy and an extensive workup for underlying causes. Many authors inferred that the measurement of anti-PLA2R1 may change the diagnostic algorithm in patients wi.. Read More»
  DOI: 10.4172/2161-0959.1000155

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