Journal of Nephrology & Therapeutics

Feng Li

Publications

• Research Article
  eNOS and Diabetic Nephropathy
  Author(s): Feng Li and Nobuyuki TakahashiFeng Li and Nobuyuki Takahashi
  
  Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD) and the number of patients with DN has been increasing rapidly. Development of new effective therapeutic strategies of DN is slow at least partly because of a lack of animal models that recapitulate the features of human DN. Human variants of the endothelial nitric oxide synthase gene (eNOS, NOS3 ) that produce reduced amounts of nitric oxide (NO) are positively associated with DN, although proof of causation is lacking. Recently, several investigators have established animal models of advanced DN using mice unable to synthesize eNOS and have demonstrated that eNOS -/- mice with diabetes develop severe nephropathy. It has been also shown that a high fat diet worsens the DN of the diabetic mice lacking eNOS. However, complete absence of eNOS has not.. Read More»
  DOI: 10.4172/2161-0959.S2-004

  Abstract PDF