Journal of AIDS & Clinical Research

Ernest ND

Publications

• Research Article
  Long Term Protease Inhibitor Monotherapy in a Two-Tiered HIV-1 Levels Design
  Author(s): Ernest ND and Michael CErnest ND and Michael C
  
  Treatment of choice in ART therapy for HIV-1 viremia remains an issue as all treatments interrupt HIV repopulation albeit at different reproductive points. The issue was addressed by grouping patients into two-tiered HIV level design of High >50,000 and Low <50,000 plasma cps/ml. The High group with 3 patients had combined class ART using NRTI plus NNRTI or PI regimens until viremia was reduced to <75 cps/ml and then PI alone. The Low group with 11 patients had PIMT regimen. CD4 T cell levels were monitored throughout. ART efficacy was assessed as total number of months of controlled (<75 cps/ml) viral infection level vs. number of months of uncontrolled levels of (>75 cps/ml). In that adherence/non-adherence to regimen is a confound, it was also assessed by rate of suppression: HIVj-HIVk/ HVj-HVn. In the High group, one patient attained long term controlled HIV viremia.. Read More»
  DOI: 10.4172/2155-6113.1000619

  Abstract PDF