Journal of Computer Science & Systems Biology

Drena Dobbs

Publications

• Review Article
  Computational Tools for Investigating RNA-Protein Interaction Partners
  Author(s): Usha K Muppirala, Benjamin A Lewis and Drena DobbsUsha K Muppirala, Benjamin A Lewis and Drena Dobbs
  
  RNA-protein interactions are important in a wide variety of cellular and developmental processes. Recently, high-throughput experiments have begun to provide valuable information about RNA partners and binding sites for many RNA-binding proteins (RBPs), but these experiments are expensive and time consuming. Thus, computational methods for predicting RNA-Protein interactions (RPIs) can be valuable tools for identifying potential interaction partners of a given protein or RNA, and for identifying likely interfacial residues in RNA-protein complexes. This review focuses on the “partner prediction” problem and summarizes available computational methods, web servers and databases that are devoted to it. New computational tools for addressing the related “interface prediction” problem are also discussed. Together, these computational met.. Read More»
  DOI: 10.4172/jcsb.1000115

  Abstract PDF