Journal of AIDS & Clinical Research

Dobromir Dimitrov

Publications

• Research Article
  Impact of Pill Sharing on Drug Resistance Due to a Wide-Scale Oral Prep Intervention in Generalized Epidemics
  Author(s): Dobromir Dimitrov, Marie-Claude Boily, Benoît R. Mâsse and Elizabeth R. BrownDobromir Dimitrov, Marie-Claude Boily, Benoît R. Mâsse and Elizabeth R. Brown
  
  Background: The first antiretroviral drug (Truvada) to be used as a pre-exposure prophylaxis (PrEP) in preventing HIV transmission is about to be approved. Behavioral studies suggest that a portion of users may share anti-retroviral drugs with sex partners, family, or friends. Pill sharing will decrease PrEP efficacy and adherence level, and potentially create an environment favorable for the development of drug resistance. We aim to evaluate the potential impact of pill sharing on the PrEP effectiveness and on the rates of drug-resistance development in heterosexual populations. Methods: A transmission dynamic model was used to assess the population-level impact of oral PrEP. The fractions of new HIV infections prevented (CPF), drug resistance prevalence and the proportion of new infections in which drug-resistant HIV is transmitted (TDR) are evaluated over fixed time periods.. Read More»
  DOI: 10.4172/2155-6113.S5-004

  Abstract PDF