Journal of Nephrology & Therapeutics

Chad W. Schmiedt

Publications

• Special Issue Article
  Effect of Spironolactone on Chronic Allograft Nephropathy in Rats
  Author(s): Steven M. Cogar, Chad W. Schmiedt, Cathy A. Brown, Michel L. Vandenplas, Christy Chessman and David J. HurleySteven M. Cogar, Chad W. Schmiedt, Cathy A. Brown, Michel L. Vandenplas, Christy Chessman and David J. Hurley
  
  Objective: Chronic allograft nephropathy (CAN) is common following renal transplantation in cats and people. Aldosterone potentiates ongoing renal injury; however its role in CAN is less defined. Spironolactone, an aldosterone receptor blocker, is protective in other rodent models of renal injury. The purpose of this study was to evaluate spironolactone on the development of CAN in a rat model Animals: Fisher and Lewis, adult, male rats. Procedures: A Lewis to Fisher model of CAN was used. Rats were divided into 4 groups, 2 nephrectomy controls (CON) and 2 transplantation (TX) groups. Two groups (a CON and TX) received tap water (0.25 ml/day orally), and the remaining 2 received spironolactone (10 mg/kg orally) daily for 16 weeks post transplantation. Serum creatinine concentration, urine-protein: urine-creati.. Read More»
  DOI: 10.4172/2161-0959.S4-004

  Abstract PDF