Chemical Sciences Journal

Highly efficient one-pot three component approach was developed for the synthesis of biological active quinazoline derivatives. By the application of visible light via SP3 C-H bond activation, desired products were obtained in high yields. The advantages of this method are application of green chemistry approach, avoidance of toxic organic solvents, easily available starting material, simple operation and shorter reaction times.

A derivative of thiourea ligand N-(p-chlorophenyl)-N'-Benzoyl thiourea (PCBT) in equimolar ratio 1:1 and its transition metal complexes CoII, NiII , CuII and ZnII were synthesized by microwave (green chemistry). The structure of ligand and its complexes have been characterized by using elemental analysis, mass Spectroscopy, FT-IR, UV-Vis., 1HNMR and 13CNMR. The geometry of the proposed structures of the chelates based on their electronic spectra, electron spin resonance (ESR) and magnetic susceptibility. The stability of complexes was studied by TGA analysis (Thermal studies). The free derivative thiourea ligand (PCBT) and its complexes were studied for antimicrobial and antifungal activity.
 

Microsponges being the polymeric drug delivery systems consist of porous microspheres that can entrap a wide range of active ingredients. Boswellic acid is a pentacyclic triterpenoid having anti-inflammatory, anti-hypertensive, anti-cancer activities. The aim of the study was to develop, characterize and formulate microsponge delivery for topical application. The Microsponges were prepared by quasi emulsion solvent diffusion method using QbD approach. Drug excipient compatibility study was carried out by FT-IR, DSC and XRD. The prepared Microsponges were further evaluated for its physicochemical properties by scanning electron microscopy (SEM), photomicroscopy, transmission electron microscopy (TEM), particle size, zeta potential, and porosity analysis. The optimized Microsponges were incorporated into gel base formulation and evaluated for in-vitro drug release, dissolution studies and ex-vivo permeability studies. Further, microsponge formulations, subjected for animal studies for skin irritation test and clinical efficacy. The present study confirmed the formation of Microsponges of Boswellic acid. It also proves the sustained release of drug through microsponge formation.