Chemical Sciences Journal

Microwave Synthesis, Spectral, Thermal, and Pharmacological Evaluation of Some Metal Complexes Containing Benzene Sulfonyl Thiourea Moiety

Abstract

Hassan AM, Abd El-Wahab ZH, Salman A A, Abd El-Rahman NM, Salama TAM, El-Tantawy ASM and Khalid MW*

Synthesis and characterization of organic ligand N-(2-chloro phenyl)-N’ benzenesulfonyl thiourea (H₂L¹) was described. The formed ligand incorporated several potential donor sites, making it a versatile complexing agent with metal ions due to the presence of the sulfonyl and thiourea groups, each solely may act as a key constituent of many biologically active species. In this work, we present the synthesis of Pt (II), Pd (II) and Au (III) metal complexes and their coordination behavior towards the unsymmetrical organic ligand (H₂L¹) using microwave-assisted irradiation. The microwave approach provides clean, shorter reaction times and enhancements in yields. The prepared metal complexes have been characterized by elemental analysis, FT-IR, 1HNMR, UV-Vis, thermal analysis and magnetic susceptibility. They were tested for their antibacterial activity against Gram positive, Gram-negative bacteria as well as fungi. Also anti-cancer assay was applied against two cell lines; breast cancer cells (MCF-7) and liver cancer cells (HepG-2). The IR spectral data indicate that the ligand H₂L¹ coordinates to metal ions through sulfonyl and thionyl groups in a tetradentate square planer manner for PdII and PtII ions while in case of AuIII it takes an octahedral shape. Based on spectrophotometric investigations, it is suggested that Pd(II), Pt(II) and Au (III) form 1:1 complexes. The molecular compositions of the complexes were proposed on the basis of chemical analyses and spectrophotometric evidences.