Journal of Biometrics & Biostatistics

ISSN: 2155-6180

Open Access

Heritability Estimation using Regression Models for Correlation


Hye-Seung Lee, Myunghee Cho Paik, Tatjana Rundek, Ralph L Sacco, Chuanhui Dong and Jeffrey P Krischer

Heritability estimates a polygenic effect on a trait for a population. Reliable interpretation of heritability is critical in planning further genetic studies to locate a gene responsible for the trait. This study accommodates both single and multiple trait cases by employing regression models for correlation parameter to infer the heritability. Sharing the properties of regression approach, the proposed methods are exible to incorporate non-genetic and/or non-additive genetic information in the analysis. The performances of the proposed model are compared with those using the likelihood approach through simulations and carotid Intima Media Thickness analysis from Northern Manhattan family Study.


Share this article

Google Scholar citation report
Citations: 2835

Journal of Biometrics & Biostatistics received 2835 citations as per Google Scholar report

Journal of Biometrics & Biostatistics peer review process verified at publons

Indexed In

arrow_upward arrow_upward