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Recent Ideas in Cancer and Cancer Genomics | Archives of Surgical Oncology
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Archives of Surgical Oncology

ISSN: 2471-2671

Open Access

Editorial

Pages: 1 - 1

International Conference on Cancer Genomics

Sergey Suchkov

The post report of International Conference on Cancer Genomics captures a programme of keynote presentations, oral talks, panel discussions and shared dialogue at the conference on leading the way in Medical and Health Science, which took place from 2nd of July 2020. Cancer Nursing Webinar brought together doctors, physicians, nurses, oncologists, professors, chief officials, entrepreneurs, researchers and also provided a treasurable networking opportunity and set the stage for more cooperation among doctors from countries at different stages of development. The webinar began with opening remarks of the conference host and continued with a set of keynote presentations of real world cases describing new and remarkable initiatives by the distinguished keynote speakers. A series of stimulating speeches to create skills in and advance awareness of requirements in cancer care was of particular interest to industry and academia. The speakers addressed topics as well as taking a look into an ambiguous future through the senses of a futurologist. Based on the theme the conference program addressed leading approaches and provided an opportunity to discuss and challenge some up-to-date practices.

Short Communication

Pages: 2 - 2

Risk factors for breast cancer in patients presented at the Khartoum Teaching Hospital

Ayda Hussein Omer Mustafa

Introduction: Breast cancer is the dominant cancer in the female in Sudan, Percentages of the breast cancers represented 38.4% to 42% of all female cancers.

Objectives: To study the risk factors for breast cancer at Khartoum teaching hospital in the study period and to compare them with the literature.

Methods: This is a prospective cross sectional hospital based study done on patients who confirmed to have breast cancer by histopathology at Khartoum
Teaching Hospital (KTH) during the period from November 2013 to November 2014.

Results: This study includes 110 patients, the age ranges from 25 -85 years, 98.2% were females, and the majority of patients (34.2%) fell in the age group
45 -54 years, the majority 34.2% originate from North, the highest incidence was in Gaalia tribe, 73.8% were married, 22.7% were single and 2.7% widowed.
Sixty one patients (54.9%) develop menarche at or below the age of 13 years old, 57.6% had their first child below the age of 31 years old, 63.9% have
children, 8.1% were nulliparous. Sixty five patients (58.5%) have a full term pregnancies and 5 patients (4.5%) have a twins, only 3 patients (2.7%) did not
breastfed, just 7.2% had menopause at 55 years or more. There were 17.1% diabetics, and 15.3% receive oral contraceptive pills. Eighteen patients (16.2%)
had a previous breast diseases, and17.1% had a family history of breast cancer. The majorities were overweight 42.3% and 89.1% were housewives, 22.7%
ate diet rich in fat, 39.1% were educated to primary school level, illiterate 27.3%, 23.6% educated to secondary school level, and15.1% to university level.
Twenty-seven patients (24.5%) were exposed to x-ray, 3 patients 2.7% to mammography radiation, and 1.8% to radiotherapy. Twenty-two patients (20%)
were taking aspirin regularly, 11.8% NSAIDs, and 12.7% antihypertensive drugs regularly, 28% had chronic illnesses. Just 2.7% were victims for insect bite.

Conclusion: North was the commonest state of origin and the Gaalia, Shawaiga and Kwahla is the mostly affected tribes, breast cancer occur in a younger age
group 45 – 54 years old. Family history, early menarche, contraceptive pills and diabetes play important role risk factors. Age at first birth, menopausal status,
breast feeding, education and socioeconomic state play less effects.

Short Communication

Pages: 3 - 3

Predictive, Precise, Personalized and Prognostic Medicine for NAFDL, NASH and Liver Cancers in Sub-Saharan Africa: Challenges, Solutions and Perspectives

Benjamin LONGO MBENZA

Background: Five P Medicine (Predictive, Personalized, Preventive, Participating, and Precise, Evidence-Based) for the Management of NAFDL, NASH, Fibrosis,
Compensated Cirrhosis, Liver Cancer, HCC Risk and Prognosis, is well established in Rich Western Countries. However, Innovations and Artificial Intelligence
such as Glycomics, Genomics, Molecular biology are lacking in Democratic Republic of the Congo (DRC).

Abstract: Thus, this lecture of the Art reports the natural history, the pathogenesis, and the prognostic value of Metabolic Hepatic Steatosis (NAFDL and NASH) for
Subclinical Hypothyroidism with Insulin Resistances, Metabolic Syndrome, Ischemic Atherosclerosis, Type 2 Diabetes Mellitus, and HCC Complex Liver diseases
(CLD) among Central Africans in Kinshasa from 2000 to 2018.

Short Communication

Pages: 4 - 4

Invasive Micropapillary Carcinoma of the Breast in Adenomatous Polyposis Coli Patient: A Case Report

Ayda Hussein Omer Mustafa

Here we present a case of rarities. IMPC mixed with benign phylloid tumor of the breast was diagnosed in a patient known to have adenomatous polyposis coli
and thyroid multinodular goitor. This is the first ever report that defines: a new form of multiple polyposis that combines IMPC and adenomatous polyposis coli;
a subtype of IMPC that is mixed with phylloid tumor; a potential transformation of fibroadenoma into 2 histologically differentiated benign and malignant tumors;
and an association between multinodular goiter and polyposis coli. To the best of our knowledge, existence of such relations has never been reported in medical
literature.
These findings are supportive of the presumed association between breast cancer and adenomatous polyps coli. They favor consideration of malignancy as a
differential for phylloid tumor. Finally, given contradicting cytological results, surgeons should rely on clinical diagnosis and support it with the more sensitive and
specific histopathology..

Short Communication

Pages: 5 - 5

Evolutionary Era for Target Therapy of Morphine Dependence in Addicted Patients

Nazila Bahmaie

Nowadays, people in several countries are coping with complications of addiction. Although, there are a wide range of studies, investigating the morbidity rate and involved agents of this disease one of the life-threatening and disastrous disease. Unfortunately, due to lack of sufficient data about complex molecular neuroimmunobiologic signaling, recent diagnostic approaches have not been efficacious for all patients, yet. These challenges will be more problematic when clinicians are witness of progressive psyconeuroendocrinologic disorders, and even overlap in diagnosis of clinical manifestations with other disorders. Hence, medical sciences progress toward more updated genetic and bioinformatics protocols in clinical trials. These protocols have facilitated more accurate prognosis and early diagnosis, eventuating to accurate immunotherapeutic purposes with less mortality and morbidity rate. Given the importance of neuro immune genes involved in inflammation and pain pathways in drug resistance and addiction, and realization of the immunopathophysiology contributing to behavioral and cognitive aspects, there is a paradigm shifts in the field of diagnostic and therapeutic approaches for addiction using molecular strategies. Thereafter, diagnostic applications of microRNAs (miRNAs) have been taken into account. MiRNAs are small conserved non-coding single-stranded endogenous RNA (19~23 nucleotides). MiRNAs exert their role through degradation or inhibition of the target mRNA translation by interaction with the 3′ untranslated region (3′UTR) of target mRNAs. Ultimately, a myriad of cell processes as: proliferation, post-translational gene expression, determination of the clinical prognosis, ectopic expression in diagnosis, evading from host immunity and targeted therapy have been regulated by host miRNAs. It has been demonstrated that alterations in serum levels of host miRNA and their target genes in pathologic microenvironment, introduces miRNA implementation as a logical approach for diagnosis. The role of miRNA in addiction to substances such as morphine, as well as tolerance to them, has been proven in many studies. Accordingly, miRNA-targeted clinical outcomes of addiction have been highly recommended.

Short Communication

Pages: 6 - 6

The Polyaniline Supported CdS/CeO2/Ag3PO4 Nanocomposite: Synthesis, Characterization and Photocatalytic Activity for Methyl Orange Dye Degradation

Tigabu Bekele

In the present work, different types of photocatalysts in single, binary and ternary systems with different molar ratios (1:1, 2:1, 3:1 and 4:1) of CdS: CeO2 /Ag3PO4 was synthesized by co- precipitation method. Polyaniline supported CdS/CeO2/Ag3PO4 nanocomposite was also synthesized by “in situ” chemical oxidative method. Crystal structure, surface area, morphology, band gap energy, functional groups, optical properties and electron transfer of the as-synthesized photocatalysts were characterized by using XRD, BET, SEM-EDX, UV/Vis, FTIR, PL and EIS instruments, respectively. Photocatalytic activities of single, binary, bare and supported ternary nanocomposite were evaluated by using aqueous solution of model pollutant methyl orange dye (MeO) as well as a real sewage sample solution collected from Bahirdar Textile Share Company.

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