It is a situation in which a substance (usually another drug) affects the activity of the drug when both are administered together. This drug action can be Synergistic means when the drug effect increased, antagonistic which means when the drug effect is decreased or a new effect can produced that neither produces on its own. If a patient is taking two drugs one of the drug may increase the effect of another drug it leads to overdose, and also increases the risk of side effects. A change in drug’s effect on the body when the drug is taken together with a second drug. There is a possibility of an interaction between a drug and another substance present in the organism and also there is one more possibility for drug-drug interaction that is interaction occur outside an organism before the administration of drugs take place.