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To evaluate the level of oxidative stress parameters and its relationship with clinical symptoms in women with fibromyalgia syndrome
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Journal of Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

To evaluate the level of oxidative stress parameters and its relationship with clinical symptoms in women with fibromyalgia syndrome


6th International Conference on Biomarkers & Clinical Research

August 31-September 02, 2015 Toronto, Canada

Ghizal Fatima, Abbas Ali Mahdi and Siddharth Kumar Das

King George├ó┬?┬?s Medical University, India

Posters-Accepted Abstracts: J Mol Biomark Diagn

Abstract :

Objective: In the present study we examined the involvement of oxidative stress in women with Fibromyalgia Syndrome (FMS) and also evaluated its correlation with the severity of its symptoms. Introduction: FMS is a common chronic pain syndrome with an unknown etiology. Increased oxidative stress results from an imbalance between products of oxidation and antioxidant defenses. There are several clinical conditions associated with increased oxidative stress, but novel data suggest a relationship between oxidative stress and pain perception. Furthermore, there is little information available in scientific literature about oxidative stress in FMS. Methods: Oxidative stress was determined by measuring the levels of Lipid Peroxides (LPO) and Protein carbonyl group in plasma in 30 female patients satisfying American College of Rheumatology (ACR) criteria for FMS and 30 healthy females without FMS. Clinical parameters of FMS were evaluated by Fibromyalgia Impact Questionnaire Revised (FIQR). Results: We found increased LPO and Protein carbonyl group in FMS patients as compared to control (p<0.01). A significant positive correlation was found between LPO and clinical symptoms of FMS among patients group. Furthermore, a significant positive correlation was also found between Protein carbonyl group and clinical symptoms of FMS among patients group in comparison to control group. Conclusion: The present results indicate that women with FMS are exposed to oxidative stress and this increased oxidative stress may play a role in the etiopathogenesis of the disease. Moreover, our results also show that increased oxidative stress parameters are more strongly associated with FMS symptoms.

Biography :

Email: ghizalfatima8@gmail.com

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Citations: 2054

Journal of Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report

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