The use of a new autologous regenerative blood-derived product for wound and lesion healing in elephants

Global Veterinary Summit

August 31- September 02, 2015 Orlando-FL, USA

Wouters G1, Behlert O2, Teschner K2 and Guldentops D1

1Fat Stem Laboratories, Belgium 2Cologne Zoo, Germanny

Posters-Accepted Abstracts: J Veterinar Sci Technolo

Abstract :

During a cowpox-infection the group (13) of elephants in Cologne Zoo developed mild to severe horn lesions in their hooves due to pox vesicles (infection-related complication) on the feet. Those vesicles undermine the (skin above the) horn and the sole, wich could lead to the loss of the horn/tissue unit and in severe cases the animalâ��s death. All lesions were surgical treated. Local treatment was done by bathing the feet daily in solutions with antiseptics and the application of wound- healing ointments and creams. Three animals suffered from multiple erosions and showed signs of pain (lameness), therefore receiving Phenylbutazon (Butazolidin�®, MSD, Animal Health, Chicago, USA). Wild animals lack cooperative behaviour, they have no possibility for containment avoiding licking and biting, and daily narcosis is not an option. As open ound persisted, a new autologous regenerative product optimised for wound healing, containing platelet rich plasma and major bioactive growth factors was used (PLTfix�®, Fat-Stem Laboratories, Aalst, Belgium). The three elephants with most severe lesions were tested. At the laboratory PLTfix�® was derived from anti-coagulated blood (100 ml). Within 72 h after blood retrieval the PLTfix�® was sent back for therapeutic one-time application to the lesion by moisturisation. PLTfix�® doses (1.5 ml) were mixed with 10 % DMSO (Wak-Chemie Medical GmBH, Steinbach, Germany), acting as a carrier additive. The first five days no changes were observed. After one week a fast growth of a firm regenerative granulation tissue was seen (full coverage). After 2 weeks the normal horn started to grow from the top and the sides. By that time lameness got resolved, indicating a decrease in inflammation and pain. Within a month the affected area was difficult to be told apart from the non-affected area in all three animals which received the PLTfix�®, but not in the other elephants. PLTfix�® proofed to stimulate wound healing andto aid rapid regenerationby a single one-time application.

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