GET THE APP

The synthesis and cytotoxic activities of imidazole [4,5-b]pyridine-2-phenyl carboxamidine derivatives
..

Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

The synthesis and cytotoxic activities of imidazole [4,5-b]pyridine-2-phenyl carboxamidine derivatives


International Conference on Histochemistry & Cell Biology

September 14-15, 2016 Phoenix, USA

Canan Kus

Ankara University, Turkey

Scientific Tracks Abstracts: J Cytol Histol

Abstract :

Some heterocyclic compounds having amidino group are present in synthetic products with a range of pharmacological effects such as antithrombotic, anti-hypercholesterolemic, antihistaminic, antihypertensive, amebicidal, antihyperglycemic, anti-inflammatory, anticancer and antibacterial activities. The synthesis of 4-(3-benzyl-3Himidazo[ 4,5-b]pyridin-2-yl)benzonitrile derivatives were performed from p-cyanobenzaldehyde. These compounds were transformed to the desired amidine derivatives (Z)-N,N├ó┬?┬?-bis(4-chlorobenzyl)-4-(3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl) benzamidine via the Pinner reaction followed by stirring the resulting imidates ethyl 4-(3-benzyl-3H-imidazo[4,5-b]pyridin- 2-yl)benzimidate in ethanolic amines. Human breast cancer cells (MCF7) and hepatocellular carcinoma cells (HepG2) were grown in a humidified incubator supplemented with 5% CO2. Fetal bovine serum (%10) and antibiotics were added in culture media. Cytotoxic concentrations (IC50 doses) of chemicals was determined by MTT (MTT [3-(4,5-dimethyl-2-thiazol-2-yl)- 2,5-diphenyl-2H-tetrazolium bromide) assay for 24, 48 and 72-hour time periods. The inhibition of cell proliferation was determined by measuring the optical density of the chromogenic product at 540 nm with an ELISA reader.

Biography :

Canan Kus has completed her PhD from Ankara University in 1998 and attained full tenure as a Professor in the year 2009. Some of the highlights of her scholarship include her Post-doctoral studies as a Researcher on a new project called “uPA (Urokinase-type Plasminogen Activator) inhibitor group studies” at University of Arizona School of Pharmacy in the year 2007 in Arizona, USA. She has published more than 29 papers in reputed journals. She has received the First Winner Prize from Novartis Drug Company Pharmaceutical for Medicinal Chemistry in the year 2007.

Email: [email protected]

50+ Million Readerbase

Recommended Conferences

Journal Highlights

Google Scholar citation report
Citations: 1837

Journal of Cytology & Histology received 1837 citations as per Google Scholar report

Journal of Cytology & Histology peer review process verified at publons

Indexed In

Recommended Conferences
 
arrow_upward arrow_upward