GET THE APP

The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence
..

Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence


3rd International Conference on Biomarkers & Clinical Research

July 2-4, 2012 Embassy Suites Las Vegas, USA

Erkki Pesonen, Seppo Sarna, Mirja Puolakkainen, Hans �hlin, Timo Sorsa and Pirkko J. Pussinen

Scientific Tracks Abstracts: J Mol Biomark Diagn

Abstract :

Introduction: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. MMPs are endogenously inhibited by the specific tissue inhibitor of metalloproteinases (TIMP-1). Methods: Sera were collected from 343 patients with ACS [including108 unstable angina pectoris and 235 acute myocardial infarctions] within 24 hours after the diagnosis and three to six months after the acute event during the recovery period (n=157). Serum MMP-8 concentrations were determined by a time-resolved immunofluorometric assay. 326 age- and sex-matched subjects served as controls. Results: The ACS patients had high IgG-class antibody levels to chlamydial heat shock protein 60 and the levels correlated with serum TIMP-1 concentrations (r=0.225, p=0.001). High serum MMP-8 and TIMP-1 concentrations (4th quartile vs. 1st) associated with ACS. The trend from quartile 1 to 4 was very significant (p<0.001). A strong direct association was found between TIMP-1 concentration and CVD death during the follow-up. Acute phase and recovery period TIMP-1 concentrations associated with cardiovascular death with hazard ratios 4.31 (2.00�9.26, p<0.001) and 4.69 (1.10�20.01, p = 0.037), respectively. Conclusions: A persistent inflammation existed before the acute event. The increase of serum MMP-8 and TIMP-1 concentrations may reflect plaque instability and tissue damage. TIMP-1 may exert a continuous damaging stimulus promoting inflammation. If TIMP-1 is �over produced� as a response to acute phase MMP-8 expression or if its production is not suppressed enough during the recovery, the prognosis is poor. The fndings may have practical implications in both diagnostics and therapeutics.

Google Scholar citation report
Citations: 2054

Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report

Molecular Biomarkers & Diagnosis peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward