Technetium 99m dimercaptosuccinic Acid Renal Scintigrafy in Children with Antenatal hydronephrosis

5^th International Conference on Kidney Failure & Renal Care

March 25-26, 2025 | London, UK

Boris Ajdinovi

Faculty of Medicine of the Military Medical Academy, Serbia

Scientific Tracks Abstracts: J Nephrol Ther

Abstract :

Objective.The purpose of this study was to evaluate damage of the kidney with Tc99m-DMSA scintigraphy in children with antenatal hydronephrosis (ANH) and the influence of other postnatal associated diagnoses on abnormal DMSA findings. Subjects and Methods. DMSA scintigraphy in 54 children (17 girls and 37 boys), aged from 2 months to 5 years ( median 11 months) with 66 antenatally detected hydronephrotic renal units (RU) ( 42 unilateral hydronephrosis – 29 boys and 13 girls; 12 bilateral hydronephrosis – 8 boys and 4 girls) was done. Male/female ratio was 2,2: 1, unilateral/bilateral hydronephrosis ratio was 4:1 Hydronephrosis classified into three groups according to ultrasound measurement of the antero-posterior pelvic diameter APD) : mild (APD 5–9.9 mm) was present in 13/66 RU, moderate (APD 10–14.9mm) in 25/66 RU, and severe (APD ≥ 15 mm) in 28/66 RU. Simple hydronephrosis was present in 15 RU, and he postnatal associated clinical diagnosis were vesicoureteric reflux (VUR) in 21, pelviureteric junction (PUJ) obstruction in 7, pyelon et ureter duplex in 11, megaureter in 11 and posterior urethra valves in 1 RU respectively. Static renal scintigraphy was performed 2 to 3 hours after intravenous (iv) injection of 99mTechnetium labeled dimercaptosuccinic acid (DMSA) using a dose of 50 μCi/kg (1.85 MBq/kg; minimal dose: 300 μCi). Four views (posterior, left and right posterior oblique and anterior) were obtained with a single head gamma camera “Orbiter” filtered with high resolution parallel whole collimator. All images were stored in an Pegasys computer with a matrix size of 256 × 256. The relative kidney uptake (RKU) between the left and right kidney was calculated as an average number counts from anterior and posterior view. Renal pathology was defined as inhomogenous or focal/multifocal uptake defects of radiofarmaceutical in hydronephrotic kidney or as split renal uptake of < 40%, and poor kidney function was defined as split renaluptake <10%. Descriptive and analytical statistics (SPSS version 20.0) was performed. Analytical statistics implied the non-parametric Mann-Whitney test for determination of statistically significant difference between the normal and pathological findings on DMSA scan. The default level of significance was p<0.05..

Biography :

Boris AjdinoviÃÂ??, Institute of Nuclear Medicine, Military Medical Academy, Belgrade, Faculty of Medicine of the Military Medical Academy, University of Difence, Belgrade, University Children’s Clinic, Belgrade University, Serbia.