Irem Bozbey
Inonu University, Turkey
Posters & Accepted Abstracts: Med chem
Although there are a large number of antiepileptic drugs (AEDs) on the market today, uncontrollable seizures related serious side effects, toxicity due to long-term use, the drugs not being tolerated well by some patients, development of resistance to drugs and drug-drug interactions are significant problems in treatment of epilepsy. Therefore, development safer, more effective, non-toxic, that can control all seizure types and selective compounds is on current and critical issue. Conventional AEDs are available in many different chemical structures such as hydantoins, barbiturates, benzodiazepines, imids, oxazolidines, sulfonamides, and valproates. Arylalkylazoles are a group of anticonvulsant compounds, which are different in structure with an azole ring, and nafimidone is one of the representatives of this group. Oxime ether derivatives of nafimidone with imidazole and triazole ring show high anticonvulsant activities. Literatures and our previous studies show that anticonvulsant properties of (arylalkyl)azoles are associated with the presence of a small oxygen functional group (such as carbonyl, methoxy, acyloxy, oxime ether, oxime ester and hydroxy) in the alkylene bridge. Therefore, in this study we aimed to synthesize and test anticonvulsant activities of 30 ester derivatives of phenyl/4- chlorophenyltriazolyl ethanone. The compounds have been synthesized according to the reaction pathways given below. Their structures were confirmed by IR, NMR, LC-MS and the elemental analysis.
Ã?°rem Bozbey is a PhD student at Gazi and Ã?°nönü University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry. She has graduated from Ã?°nönü University, Faculty of Pharmacy, Malatya, Turkey.
Email: irembzby@gmail.com
Medicinal Chemistry received 6627 citations as per Google Scholar report
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