Synergistic activity between Echinophora platyloba DC ethanolic extract and azole drugs againstclinical isolates of Candida albicans from women suffering chronic recurrent vaginitis.

Joint Conference on 6^th Annual Conference on Microbiology & Annual Conference on Microbes and Beneficial Microbes

October 16-17, 2017 Baltimore, USA

Majid Avijgan

Esfahan University of Medical Sciences, Iran

Scientific Tracks Abstracts: J Med Microb Diagn

Abstract :

Objective: Candida albicans is one of the main causes of vaginitis, especially in women with recurrent episodes. The appearance of drug resistant C. albicans and adverse effects of chemical agents have raised interest in Echinophora platyloba as one of four native species in Traditional Persian-Iranian medicine. Materials & Methods: This study evaluates the antifungal activity of ethanolic extract from dried aerial parts of E. platyloba against 27 clinical isolates of C. albicans from women suffering chronic recurrent vaginitis by micro-broth dilution assay. The synergistic effect of azoledrugs and E. platyloba ethanolic extract were also determined by disc diffusion method after determining the MIC90. Results: The results of this study showed a potent synergistic effect of E. platyloba ethanolic extract and itraconazole (P<0.01) and fluconazole (P<0.001) but an antagonistic effect between E. platyloba ethanolic extract and clotrimazole and miconazole against clinicalisolates of C. albicans. Conclusions: These results must be confirmed by clinical application and by further clinical studies.

Biography :

Majid Avijgan has completed his Doctorate (MD) from Ishafan University of Medical Sciences and Residency of Infectious Diseases for 4 years when he has Graduated as Specialist in National Board of Iran as second degree among 19 particpants. He is one of Young Professor of Iran who has been promoted to Full Professor of Infectious Diseases. He has published more than 104 papers in reputed journals and has been serving as an Editorial Board Member of some international journals- American Journal of Acupuncture and Integrative Medicine International.