Sedative, anxiolytic and analgesic effects of the ethanolic extract of Leea indica (Burm. f.) Merr. leaf

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Talha Bin Emran

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

The analgesic potential of Leea indica (Burm. f.) Merr., a Bangladeshi tribal medicinal plant was studied for the first time. The crude ethanol extract of Leea indica (Burm. f.) Merr. leaves was evaluated for its central nervous system (CNS) depressant effect using rodent behavioral models, such as hole cross, open field and thiopental sodium induced sleeping time tests for its sedative properties and an elevated plus-maze (EPM) test for its anxiolytic potential, respectively. The ethanol extract of L. indica at doses of 200 mg/kg, p. o., displayed a dose-dependent suppression of motor activity, exploratory behavior (in hole cross and open field tests) and prolongation of thiopental induced sleeping time in mice. In the EPM test, the dose of ethanol extract significantly (p < 0.05) increased exploration to and time spent by the treated mice in EPM open arms in a dose dependent manner. In addition, analgesic potential of L. indica was evaluated for centrally acting analgesic property using formalin induced licking response model and peripheral pharmacological actions using acetic acid-induced writhing test. In acetic acid-induced writhing test, all extracts at 200 mg/kg dose exhibited significant (p < 0.05) reduction of writhing response in a dose dependent manner; in formalin induced licking response model a significant (p < 0.05 - 0.001) result was comparable to the standard drug diclofenac sodium. These results provide in vivo evidence that leaves of L. indica in general have significant sedative and analgesic effects. Keywords: Neuropharmacology, open field, elevated plus-maze (EPM), medicinal plant, L. indica, analgesic.

Biography :

Mr. Talha Bin Emran has been working as a Lecturer, in the Department of Pharmacy, BGC Trust University, Bangladesh from January 2012 to till the date. Mr. Emran has published more than 20 research and review papers in reputed International and national Journal. He participated in many seminars and conferences in home to present his research activities. His research work based on Phytochmistry, Pharmacology, Molecular biology, Oncology and Bioinformatics. He is a fellow of Academy of General Education, India (FAGE) and a fellow of Ministry of Science, Information & Communication Technology (MOSICT) in the Session 2011-2012 for MS Thesis. He is a life member in Graduate Biochemist Association (GBA) and also a life member of Association of Pharmacy Professionals (APP), India. He is interested in Clinical Research, Protein Engineering, Immunology and Molecular Medicine.